Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R,4S)-1-[(9-deazaadenin-9yl)methyl]-3-hydroxy-4-(methylthio-methyl) pyrrolidine | treatment of cultured FaDu and Cal27 cells with 0.001 mM (3R,4S)-1-[(9-deazaadenin-9yl)methyl]-3-hydroxy-4-(methylthio-methyl) pyrrolidine and 0.02 mM 5'-methylthioadenosine inhibits MTAP by 96%, increases cellular 5'-methylthioadenosine concentrations, decreases polyamines, and induces apoptosis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BJ cell | - |
Homo sapiens | - |
Cal27 cell | - |
Homo sapiens | - |
FaDu cell | - |
Homo sapiens | - |
GM02037 cell | - |
Homo sapiens | - |
HNSCC cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
additional information | no expression in MCF-7, A-549, or U-87 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + phosphate | - |
Homo sapiens | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylthioadenosine phosphorylase | - |
Homo sapiens |
MTAP | - |
Homo sapiens |