Literature summary for 2.4.2.29 extracted from

Brenk, R.; Naerum, L.; Graedler, U.; Gerber, H.D.; Garcia, G.A.; Reuter, K.; Stubbs, M.T.; Klebe, G.
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis (2003), J. Med. Chem., 46, 1133-1143.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	Shigella flexneri	the enzyme is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by 7-methylamino-7-deazaguanine at the wobble position in the anticodon loop	7-aminomethyl-7-carbaguanine34 in tRNA + guanine	-	?

Organism

Organism	UniProt	Comment	Textmining
Shigella flexneri	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	-	Shigella flexneri	7-aminomethyl-7-carbaguanine34 in tRNA + guanine	-	?
guanine34 in tRNA + 7-aminomethyl-7-carbaguanine	the enzyme is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by 7-methylamino-7-deazaguanine at the wobble position in the anticodon loop	Shigella flexneri	7-aminomethyl-7-carbaguanine34 in tRNA + guanine	-	?

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Release 2023.1 (January 2023)