Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target for the design of potent drugs against Shigellosis | Zymomonas mobilis |
Crystallization (Comment) | Organism |
---|---|
enzyme-inhibitor complexes with 3,5-diaminophthalhydrazide, 4-aminophthalhydrazide, 5-aminonaphthalene-2,3-hydrazide, 5-amino-3-(1H-[1,2,4]triazole-3-yl-sulfanyl)-phthalhydrazide, 5-amino-3-(5-amino-1H-[1,2,4]triazol-3-yl-sulfanyl)-phthalhydrazide. 1.95 A crystal structure of 4-aminophthalhydrazide in complex with the enzyme | Zymomonas mobilis |
in complex with linbenzoguanine (6-aminoimidazol[4,5-g]quinazolin-8(7H)-one), hanging drop vapour diffusion method, in with 100 mM MES buffer (pH 5.5), 1 mM dithiothreitol, 8% (w/v) PEG 8000, 10% DMSO, at 20°C | Zymomonas mobilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-Dihydroxybenzoic acid | - |
Zymomonas mobilis | |
2,6-diamino-8-(2-phenylethyl)quinazolin-4(3H)-one | - |
Zymomonas mobilis | |
2,6-diaminoquinazolin-4(3H)-one | - |
Zymomonas mobilis | |
2-amino-8-methylquinazolin-4(3H)-one | - |
Zymomonas mobilis | |
2-aminoquinazolin-4(3H)-one | - |
Zymomonas mobilis | |
3,5-diaminophthalhydrazide | - |
Zymomonas mobilis | |
3,5-diaminophthalimide | - |
Zymomonas mobilis | |
4-aminophthalhydrazide | - |
Zymomonas mobilis | |
4-aminophthalimide | - |
Zymomonas mobilis | |
5-amino-3-(1H-[1,2,4]triazole-3-yl-sulfanyl)-phthalhydrazide | - |
Zymomonas mobilis | |
5-amino-3-(5-amino-1H-[1,2,4]triazol-3-yl-sulfanyl)-phthalhydrazide | - |
Zymomonas mobilis | |
6-amino-3-(2-phenylethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-amino-3-benzyl-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-amino-4-phenyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-amino-4-[2-(4-methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | - |
Zymomonas mobilis | |
6-aminoimidazol[4,5-g]quinazolin-8(7H)-one | - |
Zymomonas mobilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine34 in tRNA + 7-aminomethyl-7-carbaguanine | Zymomonas mobilis | - |
7-aminomethyl-7-carbaguanine34 in tRNA + guanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Zymomonas mobilis | - |
- |
- |
Zymomonas mobilis | P28720 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine34 in tRNA + 7-aminomethyl-7-carbaguanine | - |
Zymomonas mobilis | 7-aminomethyl-7-carbaguanine34 in tRNA + guanine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | x-ray crystallography | Zymomonas mobilis |
Synonyms | Comment | Organism |
---|---|---|
QueTGT | - |
Zymomonas mobilis |
TGT | - |
Zymomonas mobilis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
3,5-diaminophthalhydrazide | - |
Zymomonas mobilis | |
0.00048 | - |
4-aminophthalimide | - |
Zymomonas mobilis | |
0.001 | - |
2-amino-8-methylquinazolin-4(3H)-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0015 | - |
2,6-diaminoquinazolin-4(3H)-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0021 | - |
3,5-diaminophthalimide | - |
Zymomonas mobilis | |
0.0021 | - |
2-aminoquinazolin-4(3H)-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0026 | - |
2,6-diamino-8-(2-phenylethyl)quinazolin-4(3H)-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0037 | - |
6-amino-4-[2-(4-methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0041 | - |
(6-aminoimidazol[4,5-g]quinazolin-8(7H)-one) | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0069 | - |
6-amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0073 | - |
6-amino-3-(2-phenylethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.0083 | - |
4-aminophthalhydrazide | - |
Zymomonas mobilis | |
0.015 | - |
6-amino-3-benzyl-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.029 | - |
6-amino-4-phenyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | competitive inhibition, in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
0.038 | - |
5-amino-3-(1H-[1,2,4]triazole-3-yl-sulfanyl)-phthalhydrazide | - |
Zymomonas mobilis | |
0.05 | - |
6-amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | in 200 mM HEPES buffer (pH 7.3), 20 mM MgCl2 | Zymomonas mobilis | |
3 | - |
2,3-Dihydroxybenzoic acid | - |
Zymomonas mobilis |