Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
polysome | - |
Homo sapiens | 5844 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.325 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair | Homo sapiens | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of topoisomerase I | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of high mobility group proteins | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of DNA ligase | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of endonuclease | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of topoisomerase II | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of terminal deoxynucleotidyltransferase | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of histone | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of ADP-ribosyltransferase | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |