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Literature summary for 2.4.2.30 extracted from

  • Garcia-Salcedo, J.A.; Gijon, P.; Nolan, D.P.; Tebabi, P.; Pays, E.
    A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei (2003), EMBO J., 22, 5851-5862.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin TbSIR2RP1 is a nuclear protein that colocalizes with telomeric sequences and minichromosomes Trypanosoma brucei 785
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + histone H2A Trypanosoma brucei the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair nicotinamide + (ADP-D-ribosyl)-histone H2A
-
?
NAD+ + histone H2B Trypanosoma brucei the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair nicotinamide + (ADP-D-ribosyl)-histone H2B
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + histone H2A the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2A
-
?
NAD+ + histone H2A the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2A
-
?
NAD+ + histone H2B the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2B
-
?
NAD+ + histone H2B the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2B
-
?

Synonyms

Synonyms Comment Organism
NAD-dependent ADP-ribosyltransferase
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Trypanosoma brucei
TbSIR2RP1
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Trypanosoma brucei