Cloned (Comment) | Organism |
---|---|
gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Mus musculus |
gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | Mus musculus | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Homo sapiens | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95271 | TNKS1 | - |
Homo sapiens | P09874 | PARP-1 | - |
Homo sapiens | Q2NL67 | PARP-6 | - |
Homo sapiens | Q460N5 | PARP-14 | - |
Homo sapiens | Q8N5Y8 | PARP-16 | - |
Homo sapiens | Q9NR21 | PARP-11 | - |
Homo sapiens | Q9UGN5 | PARP-2 | - |
Homo sapiens | Q9UKK3 | PARP-4 | - |
Homo sapiens | Q9Y6F1 | PARP-3 | - |
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains | Mus musculus | |
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Mus musculus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
B aggressive lymphoma protein 2 | - |
Homo sapiens |
More | the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs | Mus musculus |
More | the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs | Homo sapiens |
PARP | - |
Mus musculus |
PARP | - |
Homo sapiens |
TANK1 | - |
Homo sapiens |
tankyrase I | - |
Homo sapiens |
TNKS-1 | - |
Homo sapiens |
TRF1-interacting ankyrin-related ADP-ribose polymerase | - |
Homo sapiens |