Activating Compound | Comment | Organism | Structure |
---|---|---|---|
peptide 14-3-3beta | - |
Pseudomonas aeruginosa |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) or C41 cells | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-hydroxypropyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | - |
Pseudomonas aeruginosa | |
2-(3-hydroxypropyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | - |
Pseudomonas aeruginosa | |
3-(4-methoxy-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)propanoic acid | - |
Pseudomonas aeruginosa | |
3-(4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)propanoic acid | - |
Pseudomonas aeruginosa | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid | - |
Pseudomonas aeruginosa | |
3-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)propanoic acid | inhibitor with micromolar potency | Pseudomonas aeruginosa | |
4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanoic acid | - |
Pseudomonas aeruginosa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0225 | - |
N6-etheno-NAD+ | at pH 7.5 and 22°C | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa PAK | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione Sepharose column chromatography and gel filtration | Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide 1,N6-ethenoadenine dinucleotide + (ADP-D-ribosyl)n-vH-Ras protein | - |
Pseudomonas aeruginosa | nicotinamide + ? | - |
? | |
nicotinamide 1,N6-ethenoadenine dinucleotide + (ADP-D-ribosyl)n-vH-Ras protein | - |
Pseudomonas aeruginosa PAK | nicotinamide + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyltransferase | - |
Pseudomonas aeruginosa |
ART | - |
Pseudomonas aeruginosa |
ExoS | - |
Pseudomonas aeruginosa |
exotoxin-S | - |
Pseudomonas aeruginosa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00862 | - |
3-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)propanoic acid | at pH 7.5 and 22°C | Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.019 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 3-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)propanoic acid | |
0.0249 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanoic acid | |
0.0479 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 3-(4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)propanoic acid | |
0.0524 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 2-(3-hydroxypropyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | |
0.135 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid | |
0.169 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 2-(3-hydroxypropyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | |
0.294 | - |
at pH 7.5 and 22°C | Pseudomonas aeruginosa | 3-(4-methoxy-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)propanoic acid |