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Literature summary for 2.4.2.30 extracted from

  • Valeri, M.; Zurli, V.; Ayala, I.; Colanzi, A.; Lapazio, L.; Corda, D.; Soriani, M.; Pizza, M.; Rossi Paccani, S.
    The Neisseria meningitidis ADP-ribosyltransferase NarE enters human epithelial cells and disrupts epithelial monolayer integrity (2015), PLoS ONE, 10, e0127614.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Protein Variants

Protein Variants Comment Organism
R7K inactive Neisseria meningitidis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Neisseria meningitidis 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
 x * 17000, SDS-PAGE Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor Neisseria meningitidis
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis Q9JZ10
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Neisseria meningitidis nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 17000, SDS-PAGE Neisseria meningitidis

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Neisseria meningitidis
ADPRT
-
 Neisseria meningitidis
NarE
-
 Neisseria meningitidis

General Information

General Information Comment Organism
physiological function enzyme binding to human epithelial cells leads to protein internalization, impairs human epithelial monolayer integrity, induces cell rounding, and impacts on actin cytoskeleton Neisseria meningitidis