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Literature summary for 2.4.2.31 extracted from

  • Schwarz, N.; Drouot, L.; Nicke, A.; Fliegert, R.; Boyer, O.; Guse, A.H.; Haag, F.; Adriouch, S.; Koch-Nolte, F.
    Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation (2012), PLoS ONE, 7, e41269.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.31

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P2X7(k) + NAD+ the P2X7(k) variant is sensitive to activation by ADP-ribosylation whereas the P2X7(a) variant is insensitive Homo sapiens nicotinamide + ?
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 ?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ADP-ribosylation of the P2X7(k) but not the P2X7(a) variant induces stable Ca2+ signals Homo sapiens