Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + protein L-arginine | Mus musculus | - |
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon carcinoma cell | - |
Mus musculus | - |
CT-26 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + protein L-arginine | - |
Mus musculus | nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arginine-specific ADP-ribosytransferases 1 | - |
Mus musculus |
ART1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme expression is increased in colon adenocarcinoma tissues | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme can regulate epithelial-mesenchymal transition by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and therefore plays an important role in the progression of colon carcinoma | Mus musculus |