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Literature summary for 2.4.2.31 extracted from

  • Song, G.L.; Jin, C.C.; Zhao, W.; Tang, Y.; Wang, Y.L.; Li, M.; Xiao, M.; Li, X.; Li, Q.S.; Lin, X.; Chen, W.W.; Kuang, J.
    Regulation of the RhoA/ROCK/AKT/beta-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma (2016), Int. J. Oncol., 49, 646-656.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + protein L-arginine Mus musculus
-
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon carcinoma cell
-
Mus musculus
-
CT-26 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + protein L-arginine
-
Mus musculus nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
?

Synonyms

Synonyms Comment Organism
arginine-specific ADP-ribosytransferases 1
-
Mus musculus
ART1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is increased in colon adenocarcinoma tissues up

General Information

General Information Comment Organism
physiological function the enzyme can regulate epithelial-mesenchymal transition by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and therefore plays an important role in the progression of colon carcinoma Mus musculus