Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.4 extracted from

  • Votruba, I.; Pomeisl, K.; Tloust'ova, E.; Holy, A.; Otova, B.
    Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines (2005), Biochem. Pharmacol., 69, 1517-1521.
    View publication on PubMed
Search for more literature for 2.4.2.4

Inhibitors

Inhibitors Comment Organism Structure
(R)-1-[2-(phosphonomethoxy)propyl]thymine
-
 Rattus norvegicus
(R)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine
-
 Rattus norvegicus
(R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine
-
 Rattus norvegicus
(S)-1-[2-(phosphonomethoxy)propyl]thymine
-
 Rattus norvegicus
(S)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine
-
 Rattus norvegicus
(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine
-
 Rattus norvegicus
1-[2-(phosphono-methoxy)ethyl]thymine
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
lymphoma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxythymidine + phosphate
-
 Rattus norvegicus thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PD-ECGF
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00022
-
 (R)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00034
-
 (R)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00037
-
 (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.0004
-
 (S)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00064
-
 (S)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00068
-
 (S)-1-[2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00078
-
 (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00093
-
 (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.001
-
 (S)-1-[2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.0013
-
 (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00146
-
 1-[2-(phosphono-methoxy)ethyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00173
-
 1-[2-(phosphono-methoxy)ethyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.0019
-
 (R)-1-[2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00232
-
 (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from liver, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.00255
-
 (R)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from liver, pH 6.4, 37°C, substrate: 2'-deoxythymidine Rattus norvegicus
0.0027
-
 (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine enzyme from liver, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00344
-
 (R)-1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine enzyme from liver, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus
0.00396
-
 (R)-1-[2-(phosphonomethoxy)propyl]thymine enzyme from SD-lymphoma, pH 6.4, 37°C, substrate: phosphate Rattus norvegicus