Literature summary for 2.4.2.4 extracted from

Kalman, T.I.; Lai, L.
6-Substituted 5-fluorouracil derivatives as transition state analogue inhibitors of thymidine phosphorylase (2005), Nucleosides Nucleotides Nucleic Acids, 24, 367-373.

Search for more literature for 2.4.2.4

Inhibitors

Inhibitors	Comment	Organism	Structure
5-fluoro-6-(1H-imidazol-1-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
5-fluoro-6-([[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
5-fluoro-6-[(4H-1,2,4-triazol-4-ylamino)methyl]pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
6-(1H-imidazol-1-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
6-(4H-1,2,4-triazol-4-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
6-([[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thymidine + phosphate	-	Escherichia coli	thymine + 2-deoxy-D-ribose 1-phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000051	-	5-fluoro-6-(1H-imidazol-1-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
0.00037	-	5-fluoro-6-[(4H-1,2,4-triazol-4-ylamino)methyl]pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
0.001	-	5-fluoro-6-([[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
0.0047	-	6-(1H-imidazol-1-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
0.0088	-	6-([[2-hydroxy-1-(hydroxymethyl)ethyl]amino]methyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli
0.054	-	6-(4H-1,2,4-triazol-4-ylmethyl)pyrimidine-2,4(1H,3H)-dione	-	Escherichia coli

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Release 2023.1 (January 2023)