Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of thymidine phosphorylase, TP, and uridine phosphorylase, UP, EC 2.4.2.3, double knockout mice, TP-/-UP-/- by insertion mutagenesis, which show severe TP deficiency, increased thymidine and deoxyuridine levels in tissues and elevated mitochondrial deoxythymidine triphosphate. As consequences of the nucleotide pool imbalances, brains of mutant mice developed partial depletion of mtDNA, deficiencies of respiratory chain complexes and encephalopathy, accounting for the pathogenesis of mitochondrial neurogastrointestinal encephalopathy, overview. Mitochondria respiratory chain deficiency in the brain of TP-/-UP-/- mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | Mus musculus | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r | |
thymidine + phosphate | Mus musculus C57Bl6/J | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57Bl6/J mice | - |
Mus musculus C57Bl6/J | - |
C57Bl6/J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
small intestine | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
no activities in other tissues than liver from TP-/-UP-/- mice | Mus musculus |
0.00002 | - |
wild-type mouse muscle | Mus musculus |
0.000205 | - |
wild-type mouse heart | Mus musculus |
0.000243 | - |
TP-/-UP-/- mouse liver | Mus musculus |
0.000285 | - |
wild-type mouse spleen | Mus musculus |
0.00067 | - |
wild-type mouse kidney | Mus musculus |
0.000862 | - |
wild-type mouse lung | Mus musculus |
0.00136 | - |
wild-type mouse brain | Mus musculus |
0.0014 | - |
wild-type mouse liver | Mus musculus |
0.00946 | - |
wild-type mouse small intestine | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | - |
Mus musculus | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r | |
thymidine + phosphate | - |
Mus musculus C57Bl6/J | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r |