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Literature summary for 2.4.2.46 extracted from

  • Alderwick, L.J.; Seidel, M.; Sahm, H.; Besra, G.S.; Eggeling, L.
    Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis (2006), J. Biol. Chem., 281, 15653-15661.
    View publication on PubMed
Search for more literature for 2.4.2.46

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a Corynebacterium glutamicum AftA-deficient mutant strain and in Escherichia coli C43 (DE3) cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by ethambutol Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan Mycobacterium tuberculosis ?
-
 ?
beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

Synonyms Comment Organism
AftA
-
 Mycobacterium tuberculosis
arabinofuranosyltransferase A
-
 Mycobacterium tuberculosis
Rv3792
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction a deletion of the AftA gene leads to complete absence of arabinose resulting in a truncated cell wall structure possessing only a galactan core with a concomitant loss of cell wall-bound mycolates Mycobacterium tuberculosis
physiological function the enzyme is involved in cell wall arabinan biosynthesis Mycobacterium tuberculosis