Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens | |
AMP | - |
Homo sapiens | |
citrate | - |
Homo sapiens | |
GMP | - |
Homo sapiens | |
Hg2+ | - |
Homo sapiens | |
iodoacetate | - |
Homo sapiens | |
Na+ | - |
Homo sapiens | |
nucleotides | nucleotide mono-, di- and triphosphates of adenine, guanine and hypoxanthine | Homo sapiens | |
p-hydroxymercuribenzoate | not enzyme from monkey liver | Homo sapiens | |
SO42- | - |
Homo sapiens | |
succinate | - |
Homo sapiens | |
sulfhydryl reagents | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | |
0.14 | - |
adenine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | exclusively | Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Co2+ | - |
Homo sapiens | |
Mg2+ | required | Homo sapiens | |
Mg2+ | absolute requirement | Homo sapiens | |
Mg2+ | Mg2+ most effective | Homo sapiens | |
Mg2+ | maximal activity if Mg2+ is twice the concentration of 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
additional information | descendring order of efficency: Mg2+, Mn2+, Ca2+, Co2+, Ni2+, Zn2+ | Homo sapiens | |
additional information | activity absolutely depends on presence of divalent cations | Homo sapiens | |
Ni2+ | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
gel filtration, sucrose density gradient ultracentrifugation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
additional information | human enzyme found in all tissues with the highest specific activity in nucleated cells | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9.58 | - |
purified enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 2,6-diaminopurine ribotide + diphosphate | - |
? | |
4-amino-5-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 4-amino-5-imidazolecarboxamide ribotide + diphosphate | - |
? | |
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 6-mercaptopurine ribotide + diphosphate | - |
? | |
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | highly specific for the donor substrate | Homo sapiens | AMP + diphosphate | - |
? | |
additional information | no substrate: adenosine | Homo sapiens | ? | - |
? | |
additional information | no substrate: hypoxanthine,guanine | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pI: 4.85 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.4 | 9.5 | broad maximum | Homo sapiens |