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Literature summary for 2.4.2.8 extracted from

  • Heroux, A.; White, E.L.; Ross, L.J.; Borhani, D.W.
    Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex (1999), Biochemistry, 38, 14485-14494.
    View publication on PubMed
Search for more literature for 2.4.2.8

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallization in complex with GMP and IMP, structure analysis Toxoplasma gondii

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii Q26997
-
-

Reaction

Reaction Comment Organism Reaction ID
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate catalytic mechanism Toxoplasma gondii
a
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate active site structure Toxoplasma gondii
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii GMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii IMP + diphosphate
-
 ?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii XMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
More structure determination and analysis Toxoplasma gondii
tetramer
-
 Toxoplasma gondii