Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GMP | 0.05 mM, at least 2fold stimulation, hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae | |
IMP | 0.2 mM, at least 2fold stimulation, hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae | |
additional information | hypoxanthine phosphoribosyltransferase activity is unaffected by AMP | Methanococcus voltae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GMP | 0.3 mM, 50% inhibition of guanine phosphoribosyltransferase activity | Methanococcus voltae | |
guanine | 0.06 mM, 50% inhibition of hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae | |
hypoxanthine | 0.16 mM, 50% inhibition of guanine phosphoribosyltransferase activity | Methanococcus voltae | |
additional information | guanine phosphoribosyltransferase activity: IMP and AMP are not inhibitory at concentrations up to 0.6 mM, adenine and xanthine are not inhibitory at concentrations up to 0.5 mM. Adenine and xanthine do not inhibit hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
hypoxanthine | pH 9.0, 37°C | Methanococcus voltae | |
0.2 | - |
guanine | pH 9.0, 37°C | Methanococcus voltae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanococcus voltae | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00085 | - |
pH 9.0, 37°C, hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae |
0.0027 | - |
pH 9.0, 37°C, guanine phosphoribosyltransferase activity | Methanococcus voltae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Methanococcus voltae | GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Methanococcus voltae | IMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guanine PRTase | - |
Methanococcus voltae |
hypoxanthine PRTase | - |
Methanococcus voltae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
guanine phosphoribosyltransferase activity and hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 10 | half-maximal activity at pH 7.5, and 10.0, guanine phosphoribosyltransferase activity | Methanococcus voltae |
7.5 | 9.5 | half-maximal activity at pH 7.5, and 9.5, hypoxanthine phosphoribosyltransferase activity | Methanococcus voltae |