Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.99.20 extracted from

  • Rah, S.Y.; Mushtaq, M.; Nam, T.S.; Kim, S.H.; Kim, U.H.
    Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells (2010), J. Biol. Chem., 285, 21877-21887.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.99.20

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus P56528
-
-

General Information

General Information Comment Organism
physiological function calcium signaling messengers nicotinate-adenine dinucleotide phosphate and 2'-phospho-cyclic ADP-ribose are not produced when lymphokine-activated killer cells prepared from CD38 knock-out mice are treated with interleukin IL-8. Application of 2'-phospho-cyclic ADP-ribose to lymphikine-activated killer cells induces nicotinate-adenine dinucleotide phosphate production, whereas nicotinate-adenine dinucleotide phosphate fails to increase intracellular 2'-phospho-cyclic ADP-ribose levels. IL-8-induced nicotinate-adenine dinucleotide phosphate production is mediated by CD38 activation through the actions of cAMP/Epac/protein kinaseA/Rap1 in lymphokine-activated killer cells and nicotinate-adenine dinucleotide phosphate plays a key role in Ca2+ signaling of IL-8-induced lymphokine-activated killer cell migration. Mus musculus