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Literature summary for 2.5.1.106 extracted from
- Mechanism of formation of the nonstandard product in the prenyltransferase reaction of the G115T mutant of FtmPT1 A case of reaction dynamics calling the shots? (2017), Biochemistry, 56, 2995-3007 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G115T | the mutant produces a five-membered ring compound as the major product with tryprostatin B as the minor product | Aspergillus fumigatus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylallyl diphosphate + brevianamide F | Aspergillus fumigatus | - |
diphosphate + tryprostatin B | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fumigatus | Q4WAW7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylallyl diphosphate + brevianamide F | - |
Aspergillus fumigatus | diphosphate + tryprostatin B | - |
? | |
| dimethylallyl diphosphate + brevianamide F | the reaction occurs with mutant enzyme G115T | Aspergillus fumigatus | diphosphate + (5aS,6aR,11aS,13aS)-6a-(2-methylbut-3-en-2-yl)-2,3,6,6a,11,11a-hexahydro-1H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-5,13(5aH,13aH)-dione + tryprostatin B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FtmPT1 | - |
Aspergillus fumigatus |
| indole prenyltransferase | - |
Aspergillus fumigatus |
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