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Literature summary for 2.5.1.108 extracted from

  • Liu, S.; Milne, G.T.; Kuremsky, J.G.; Fink, G.R.; Leppla, S.H.
    Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 (2004), Mol. Cell. Biol., 24, 9487-9497.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2] Saccharomyces cerevisiae the enzyme is involved in diphthamide biosynthesis S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2]
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 ?
S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2] Mus musculus the enzyme is involved in diphthamide biosynthesis S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2]
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9CR25
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-
Saccharomyces cerevisiae P32461
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-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] The relevant histidine of translation elongation factor 2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii Mus musculus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2] the enzyme is involved in diphthamide biosynthesis Saccharomyces cerevisiae S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2]
-
 ?
S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2] the enzyme is involved in diphthamide biosynthesis Mus musculus S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2]
-
 ?

Synonyms

Synonyms Comment Organism
Dph2
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 Mus musculus
Dph2
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction mutation in DPH2 blocks diphthamide biosynthesis Saccharomyces cerevisiae
physiological function required for diphthamide biosynthesis Mus musculus
physiological function the enzyme is involved in diphthamide biosynthesis Mus musculus
physiological function the enzyme is involved in diphthamide biosynthesis Saccharomyces cerevisiae