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Literature summary for 2.5.1.108 extracted from

  • Webb, T.R.; Cross, S.H.; McKie, L.; Edgar, R.; Vizor, L.; Harrison, J.; Peters, J.; Jackson, I.J.
    Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development (2008), J. Cell Sci., 121, 3140-3145.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and in NIH-3T3 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton
-
 Mus musculus 5856
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
DPH4
-
 Mus musculus

General Information

General Information Comment Organism
malfunction loss of Dph4 results in lack of diphthamide modification of eEF2 and resistance to diphtheria toxin. Dph4 mutant mice are growth retarded and have a specific digit defect with one or more additional preaxial digits Mus musculus