Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli | Aspergillus versicolor |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
brevianamide F | pH 7.5, 37°C | Aspergillus versicolor | |
0.032 | - |
brevianamide F | 37°C, pH 7.5 | Aspergillus versicolor | |
0.082 | - |
cyclo-L-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.082 | - |
cyclo-L-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.094 | - |
cyclo-L-Trp-L-Phe | pH 7.5, 37°C | Aspergillus versicolor | |
0.094 | - |
cyclo-L-Trp-L-Phe | 37°C, pH 7.5 | Aspergillus versicolor | |
0.098 | - |
dimethylallyl diphosphate | pH 7.5, 37°C | Aspergillus versicolor | |
0.098 | - |
dimethylallyl diphosphate | 37°C, pH 7.5 | Aspergillus versicolor | |
0.106 | - |
cyclo-L-Trp-L-Leu | pH 7.5, 37°C | Aspergillus versicolor | |
0.106 | - |
cyclo-L-Trp-L-Leu | 37°C, pH 7.5 | Aspergillus versicolor | |
0.139 | - |
cyclo-D-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.214 | - |
cyclo-L-Trp-L-Tyr | pH 7.5, 37°C | Aspergillus versicolor | |
0.214 | - |
cyclo-L-Trp-L-Tyr | 37°C, pH 7.5 | Aspergillus versicolor | |
0.709 | - |
cyclo-D-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.709 | - |
cyclo-D-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.793 | - |
cyclo-L-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.793 | - |
cyclo-L-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.942 | - |
cyclo-L-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.942 | - |
cyclo-L-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
1.3 | - |
cyclo-L-Trp-Gly | pH 7.5, 37°C | Aspergillus versicolor | |
1.3 | - |
cyclo-L-Trp-Gly | 37°C, pH 7.5 | Aspergillus versicolor | |
1.318 | - |
cyclo-D-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
1.318 | - |
cyclo-D-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
1.318 | - |
cyclo-D-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
2.906 | - |
cyclo-D-Trp-L-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
2.906 | - |
cyclo-D-Trp-L-Pro | 37°C, pH 7.5 | Aspergillus versicolor |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, SDS-PAGE | Aspergillus versicolor |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + brevianamide F | Aspergillus versicolor | - |
diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | Aspergillus versicolor NRRL 573 | - |
diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | Aspergillus versicolor NRRL573 | - |
diphosphate + deoxybrevianamide E | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus versicolor | I4AY86 | - |
- |
Aspergillus versicolor NRRL 573 | I4AY86 | - |
- |
Aspergillus versicolor NRRL573 | I4AY86 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Aspergillus versicolor |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + brevianamide F | - |
Aspergillus versicolor | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | the enzyme accepts a broad range of tryptophan-containing cyclic dipeptides, no activity with farnesyl diphosphate and geranyl diphosphate | Aspergillus versicolor | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | i.e. cyclo-L-Trp-L-Pro | Aspergillus versicolor | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | - |
Aspergillus versicolor NRRL 573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | the enzyme accepts a broad range of tryptophan-containing cyclic dipeptides, no activity with farnesyl diphosphate and geranyl diphosphate | Aspergillus versicolor NRRL 573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | i.e. cyclo-L-Trp-L-Pro | Aspergillus versicolor NRRL 573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | - |
Aspergillus versicolor NRRL573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | the enzyme accepts a broad range of tryptophan-containing cyclic dipeptides, no activity with farnesyl diphosphate and geranyl diphosphate | Aspergillus versicolor NRRL573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + brevianamide F | i.e. cyclo-L-Trp-L-Pro | Aspergillus versicolor NRRL573 | diphosphate + deoxybrevianamide E | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-D-Ala | - |
Aspergillus versicolor | diphosphate + | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-D-Ala | - |
Aspergillus versicolor NRRL 573 | diphosphate + | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-D-Ala | - |
Aspergillus versicolor NRRL573 | diphosphate + | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-D-Ala | - |
Aspergillus versicolor | diphosphate + ? | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-D-Pro | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-D-Trp]-D-Pro | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-L-Ala | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-D-Trp]-L-Ala | - |
? | |
dimethylallyl diphosphate + cyclo-D-Trp-L-Pro | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-D-Trp]-L-Pro | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-D-Ala | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-D-Ala | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-D-Pro | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-D-Pro | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-Gly | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-Gly | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Ala | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-L-Ala | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Ala | - |
Aspergillus versicolor | diphosphate + ? | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Leu | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-L-Leu | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Phe | - |
Aspergillus versicolor | diphosphate + | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Phe | - |
Aspergillus versicolor | diphosphate + ? | - |
? | |
dimethylallyl diphosphate + cyclo-L-Trp-L-Tyr | - |
Aspergillus versicolor | diphosphate + cyclo-[2-(2-methylbut-3-en-2-yl)-L-Trp]-L-Tyr | - |
? | |
additional information | enzyme shows high flexibility towards its aromatic substrates and accepts all of the 14 tested tryptophan-containing cyclic dipeptides. The enzyme catalyzes the highly regiospecific reverse prenylation at C2 of the indole nucleus | Aspergillus versicolor | ? | - |
? | |
additional information | enzyme shows high flexibility towards its aromatic substrates and accepts all of the 14 tested tryptophan-containing cyclic dipeptides. The enzyme catalyzes the highly regiospecific reverse prenylation at C2 of the indole nucleus | Aspergillus versicolor NRRL 573 | ? | - |
? | |
additional information | enzyme shows high flexibility towards its aromatic substrates and accepts all of the 14 tested tryptophan-containing cyclic dipeptides. The enzyme catalyzes the highly regiospecific reverse prenylation at C2 of the indole nucleus | Aspergillus versicolor NRRL573 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, SDS-PAGE | Aspergillus versicolor |
Synonyms | Comment | Organism |
---|---|---|
BrePT | - |
Aspergillus versicolor |
brevianamide F reverse prenyltransferase | - |
Aspergillus versicolor |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
cyclo-D-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.003 | - |
cyclo-D-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.004 | - |
cyclo-L-Trp-L-Phe | pH 7.5, 37°C | Aspergillus versicolor | |
0.004 | - |
cyclo-L-Trp-L-Phe | 37°C, pH 7.5 | Aspergillus versicolor | |
0.006 | - |
cyclo-L-Trp-L-Tyr | pH 7.5, 37°C | Aspergillus versicolor | |
0.006 | - |
cyclo-L-Trp-L-Tyr | 37°C, pH 7.5 | Aspergillus versicolor | |
0.011 | - |
cyclo-D-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.011 | - |
cyclo-D-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.013 | - |
cyclo-L-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.013 | - |
cyclo-L-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.014 | - |
cyclo-L-Trp-L-Leu | pH 7.5, 37°C | Aspergillus versicolor | |
0.014 | - |
cyclo-L-Trp-L-Leu | 37°C, pH 7.5 | Aspergillus versicolor | |
0.027 | - |
cyclo-D-Trp-L-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.027 | - |
cyclo-D-Trp-L-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.032 | - |
cyclo-L-Trp-Gly | pH 7.5, 37°C | Aspergillus versicolor | |
0.032 | - |
cyclo-L-Trp-Gly | 37°C, pH 7.5 | Aspergillus versicolor | |
0.035 | - |
cyclo-L-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.035 | - |
cyclo-L-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.095 | - |
cyclo-D-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.095 | - |
cyclo-D-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.15 | - |
cyclo-L-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.15 | - |
cyclo-L-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.276 | - |
brevianamide F | pH 7.5, 37°C | Aspergillus versicolor | |
0.276 | - |
brevianamide F | 37°C, pH 7.5 | Aspergillus versicolor | |
0.489 | - |
dimethylallyl diphosphate | 37°C, pH 7.5 | Aspergillus versicolor | |
0.49 | - |
dimethylallyl diphosphate | pH 7.5, 37°C | Aspergillus versicolor |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
cyclo-D-Trp-L-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.009 | - |
cyclo-D-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.009 | - |
cyclo-D-Trp-L-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.009 | - |
cyclo-D-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.017 | - |
cyclo-L-Trp-D-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.017 | - |
cyclo-L-Trp-D-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.021 | - |
cyclo-D-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.021 | - |
cyclo-D-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.025 | - |
cyclo-L-Trp-Gly | pH 7.5, 37°C | Aspergillus versicolor | |
0.025 | - |
cyclo-L-Trp-Gly | 37°C, pH 7.5 | Aspergillus versicolor | |
0.027 | - |
cyclo-L-Trp-L-Tyr | pH 7.5, 37°C | Aspergillus versicolor | |
0.027 | - |
cyclo-L-Trp-L-Tyr | 37°C, pH 7.5 | Aspergillus versicolor | |
0.037 | - |
cyclo-L-Trp-L-Ala | pH 7.5, 37°C | Aspergillus versicolor | |
0.037 | - |
cyclo-L-Trp-L-Ala | 37°C, pH 7.5 | Aspergillus versicolor | |
0.04 | - |
cyclo-L-Trp-L-Phe | pH 7.5, 37°C | Aspergillus versicolor | |
0.04 | - |
cyclo-L-Trp-L-Phe | 37°C, pH 7.5 | Aspergillus versicolor | |
0.13 | - |
cyclo-D-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
0.13 | - |
cyclo-D-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
0.134 | - |
cyclo-L-Trp-L-Leu | pH 7.5, 37°C | Aspergillus versicolor | |
0.134 | - |
cyclo-L-Trp-L-Leu | 37°C, pH 7.5 | Aspergillus versicolor | |
1.8 | - |
cyclo-L-Trp-D-Pro | pH 7.5, 37°C | Aspergillus versicolor | |
1.83 | - |
cyclo-L-Trp-D-Pro | 37°C, pH 7.5 | Aspergillus versicolor | |
4.99 | - |
dimethylallyl diphosphate | pH 7.5, 37°C | Aspergillus versicolor | |
4.99 | - |
dimethylallyl diphosphate | 37°C, pH 7.5 | Aspergillus versicolor | |
8.6 | - |
brevianamide F | pH 7.5, 37°C | Aspergillus versicolor | |
8.64 | - |
brevianamide F | 37°C, pH 7.5 | Aspergillus versicolor |