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Literature summary for 2.5.1.15 extracted from

  • Walter, R.D.; Königk, E.
    Biosynthesis of folic acid compounds in plasmodia. Purification and properties of the 7,8-dihydropteroate-synthesizing enzyme from Plasmodium chabaudi (1974), Hoppe-Seyler's Z. Physiol. Chem., 355, 431-437.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
Plasmodium chabaudi
p-Aminobenzoate
-
Plasmodium chabaudi
p-Aminosalicylic acid
-
Plasmodium chabaudi
Sulfaguanidine
-
Plasmodium chabaudi
sulfanilamide
-
Plasmodium chabaudi
Sulfanilic acid
-
Plasmodium chabaudi
sulfathiazole competitive to 4-aminobenzoate Plasmodium chabaudi
sulfonamide competitive to 4-aminobenzoate Plasmodium chabaudi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
4-Aminobenzoate
-
Plasmodium chabaudi

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required to synthesize product Plasmodium chabaudi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
190000
-
Sephadex chromatography Plasmodium chabaudi

Organism

Organism UniProt Comment Textmining
Plasmodium chabaudi
-
-
-

Purification (Commentary)

Purification (Comment) Organism
precipitation with ammonium sulfate followed by column chromatography Plasmodium chabaudi

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Plasmodium chabaudi
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
15.78
-
-
Plasmodium chabaudi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Plasmodium chabaudi diphosphate + 7,8-dihydropteroate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.7
-
-
Plasmodium chabaudi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.023
-
p-Aminosalicylic acid
-
Plasmodium chabaudi
0.043
-
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
Plasmodium chabaudi
0.069
-
Sulfaguanidine
-
Plasmodium chabaudi
0.13
-
sulfanilamide
-
Plasmodium chabaudi
0.14
-
Sulfanilic acid
-
Plasmodium chabaudi