Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine | - |
Plasmodium chabaudi | |
p-Aminobenzoate | - |
Plasmodium chabaudi | |
p-Aminosalicylic acid | - |
Plasmodium chabaudi | |
Sulfaguanidine | - |
Plasmodium chabaudi | |
sulfanilamide | - |
Plasmodium chabaudi | |
Sulfanilic acid | - |
Plasmodium chabaudi | |
sulfathiazole | competitive to 4-aminobenzoate | Plasmodium chabaudi | |
sulfonamide | competitive to 4-aminobenzoate | Plasmodium chabaudi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
4-Aminobenzoate | - |
Plasmodium chabaudi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required to synthesize product | Plasmodium chabaudi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
190000 | - |
Sephadex chromatography | Plasmodium chabaudi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium chabaudi | - |
- |
- |
Purification (Comment) | Organism |
---|---|
precipitation with ammonium sulfate followed by column chromatography | Plasmodium chabaudi |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Plasmodium chabaudi | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
15.78 | - |
- |
Plasmodium chabaudi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Plasmodium chabaudi | diphosphate + 7,8-dihydropteroate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.7 | - |
- |
Plasmodium chabaudi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
p-Aminosalicylic acid | - |
Plasmodium chabaudi | |
0.043 | - |
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine | - |
Plasmodium chabaudi | |
0.069 | - |
Sulfaguanidine | - |
Plasmodium chabaudi | |
0.13 | - |
sulfanilamide | - |
Plasmodium chabaudi | |
0.14 | - |
Sulfanilic acid | - |
Plasmodium chabaudi |