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Literature summary for 2.5.1.15 extracted from
- Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori (2007), J. Bacteriol., 189, 4062-4069.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Helicobacter pylori |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G58A | site-directed mutagenesis, cannot replace DHPR in Escherichia coli, affects the binding affinity for FMN | Helicobacter pylori |
| K31A | site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN | Helicobacter pylori |
| K51A | site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN | Helicobacter pylori |
| K92E | site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN | Helicobacter pylori |
| M28E | site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN | Helicobacter pylori |
| additional information | DHPS contains also dihydropteroate reductase activity | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | Helicobacter pylori | - |
diphosphate + 7,8-dihydropteroate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | Q49HL6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate | - |
Helicobacter pylori | diphosphate + 7,8-dihydropteroate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7,8-dihydropteroate synthase | - |
Helicobacter pylori |
| DHPS | - |
Helicobacter pylori |
| DHPS/DHPR | - |
Helicobacter pylori |
| dihydropteroate synthase | - |
Helicobacter pylori |
| FolP | - |
Helicobacter pylori |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin adenine dinucleotide | - |
Helicobacter pylori | |
| FMN | - |
Helicobacter pylori | |
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Release 2023.1 (January 2023)
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