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Literature summary for 2.5.1.16 extracted from

  • Shirahata, A.; Morohoshi, T.; Samejima, K.
    trans-4-Methylcyclohexylamine, a potent new inhibitor of spermidine synthase (1988), Chem. Pharm. Bull., 36, 3220-3222.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cyclohexylamine 50% inhibition at 0.0081 mM, competitive with 1,4-diaminobutane Sus scrofa
S-Adenosyl-1,8-diamino-3-thiooctane 50% inhibition at 0.0025 mM Sus scrofa
trans-4-Methylcyclohexylamine potent, 50% inhibition at 0.0017 mM, competitive with 1,4-diaminobutane Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Sus scrofa
-
5'-methylthioadenosine + spermidine
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
pig
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
Sus scrofa 5'-methylthioadenosine + spermidine
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
Sus scrofa 5'-methylthioadenosine + spermidine
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
trans-4-Methylcyclohexylamine
-
Sus scrofa