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Literature summary for 2.5.1.16 extracted from

  • Roberts, S.C.; Jiang, Y.; Gasteier, J.; Frydman, B.; Marton, L.J.; Heby, O.; Ullman, B.
    Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs (2007), Antimicrob. Agents Chemother., 51, 438-445.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.16

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the enzyme in strain clone DI700 episomes Leishmania donovani

Protein Variants

Protein Variants Comment Organism
additional information a strain overexpressing the enzyme shows a high level of resistance to n-butylamine, overview Leishmania donovani

Inhibitors

Inhibitors Comment Organism Structure
Berenil
-
 Leishmania donovani
CGC-11038 polyamine analogue Leishmania donovani
CGC-11098 polyamine analogue Leishmania donovani
CGC-11099 polyamine analogue Leishmania donovani
CGC-11108 polyamine analogue Leishmania donovani
CGC-11114 polyamine analogue Leishmania donovani
CGC-11121 polyamine analogue Leishmania donovani
CGC-11122 polyamine analogue Leishmania donovani
CGC-11144 polyamine analogue Leishmania donovani
CGC-11150 polyamine analogue Leishmania donovani
CGC-11157 polyamine analogue Leishmania donovani
CGC-11158 polyamine analogue Leishmania donovani
CGC-11159 polyamine analogue Leishmania donovani
CGC-11160 polyamine analogue Leishmania donovani
CGC-11172 polyamine analogue Leishmania donovani
CGC-11175 polyamine analogue Leishmania donovani
CGC-11207 polyamine analogue Leishmania donovani
CGC-11211 polyamine analogue Leishmania donovani
CGC-11217 polyamine analogue Leishmania donovani
CGC-11226 polyamine analogue Leishmania donovani
CGC-11227 polyamine analogue Leishmania donovani
CGC-11231 polyamine analogue Leishmania donovani
CGC-11235 polyamine analogue Leishmania donovani
CGC-11237 polyamine analogue Leishmania donovani
CGC-11239 polyamine analogue Leishmania donovani
CGC-11241 polyamine analogue Leishmania donovani
mitoguazone
-
 Leishmania donovani
additional information inhibitory potency of diverse polyamine analogues on the polyamine biosynthesis in wild-type strain and strains overexpressing polyamine biosynthetic enzymes, EC50 values, overview Leishmania donovani
n-butylamine specific inhibitor of the enzyme in vivo and in vitro Leishmania donovani
Pentamidine
-
 Leishmania donovani

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information episome Leishmania donovani
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosylmethioninamine + putrescine Leishmania donovani polyamine biosynthetic enzyme 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
 clone DI700
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosylmethioninamine + putrescine
-
 Leishmania donovani 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?
S-adenosylmethioninamine + putrescine polyamine biosynthetic enzyme Leishmania donovani 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Synonyms

Synonyms Comment Organism
SPDSYN
-
 Leishmania donovani
spermidine synthase
-
 Leishmania donovani