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Literature summary for 2.5.1.17 extracted from

  • Mudd, S.H.
    The adenosyltransferases (1973), The Enzymes, 3rd. Ed. (Boyer P. D. ed. ), 8, 121-154.
No PubMed abstract available
Search for more literature for 2.5.1.17

Inhibitors

Inhibitors Comment Organism Structure
diphosphate
-
 Clostridium tetanomorphum
EDTA
-
 Clostridium tetanomorphum
Trimetaphosphate
-
 Clostridium tetanomorphum
tripolyphosphate
-
 Clostridium tetanomorphum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 cyanocob(I)alamin
-
 Clostridium tetanomorphum
0.016
-
 ATP
-
 Clostridium tetanomorphum

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activation, less effective than Mn2+ Clostridium tetanomorphum
K+
-
 Propionibacterium freudenreichii subsp. shermanii
K+
-
 Clostridium tetanomorphum
Mg2+
-
 Propionibacterium freudenreichii subsp. shermanii
Mg2+ activation, less effective than Mn2+ Clostridium tetanomorphum
Mn2+
-
 Clostridium tetanomorphum
additional information no activation by Ca2+ or Cd2+ Propionibacterium freudenreichii subsp. shermanii
additional information no activation by Ca2+ or Cd2+ Clostridium tetanomorphum
Zn2+
-
 Propionibacterium freudenreichii subsp. shermanii
Zn2+ activation, less effective than Mn2+ Clostridium tetanomorphum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cob(I)alamin Propionibacterium freudenreichii subsp. shermanii
-
 triphosphate + coenzyme B12
-
 ?
ATP + cob(I)alamin Clostridium tetanomorphum
-
 triphosphate + coenzyme B12
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium tetanomorphum
-
-
-
Propionibacterium freudenreichii subsp. shermanii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protamine sulfate, heat treatment and chromatography on Sephadex G-25 and DEAE-cellulose Clostridium tetanomorphum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cob(I)alamin
-
 Propionibacterium freudenreichii subsp. shermanii triphosphate + coenzyme B12
-
 ?
ATP + cob(I)alamin
-
 Clostridium tetanomorphum triphosphate + coenzyme B12
-
 ?
ATP + cob(I)alamin
-
 Propionibacterium freudenreichii subsp. shermanii triphosphate + coenzyme B12 adenosylcobalamin, B12-coenzyme or deoxyadenosyl-B12 ?
ATP + cob(I)alamin
-
 Clostridium tetanomorphum triphosphate + coenzyme B12 adenosylcobalamin, B12-coenzyme or deoxyadenosyl-B12 r
cyanocob(I)alamin + ATP
-
 Clostridium tetanomorphum tripolyphosphate + alpha-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide
-
 ?
additional information UTP, GTP, ITP are poor substrates Clostridium tetanomorphum ?
-
 ?
additional information S-adenosylmethionine, vitamin B12r or B12a, AMP, ADP are no substrates Clostridium tetanomorphum ?
-
 ?
additional information hydroxocobamides or cyanocobamides in which benzimidazole replaces 5,6-dimethylbenzimidazole, or cyanocobamide in which an adenine group replaces 5,6-dimethylbenzimidazole, can also act as substrates Propionibacterium freudenreichii subsp. shermanii ?
-
 ?
additional information hydroxocobamides or cyanocobamides in which benzimidazole replaces 5,6-dimethylbenzimidazole, or cyanocobamide in which an adenine group replaces 5,6-dimethylbenzimidazole, can also act as substrates Clostridium tetanomorphum ?
-
 ?