Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bilirubin | 50% inhibition at 0.01-0.02 mM | Homo sapiens | |
Hematin | non competitive with transferase activity | Homo sapiens | |
N-ethylmaleimide | completely inhibits form IX and X at 20 mM after 30 min, but not forms I-VIII | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25200 | - |
2 * 25200, form I-XII, SDS-PAGE | Homo sapiens |
25600 | - |
2 * 25600, form XIII, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
13 forms | - |
Purification (Comment) | Organism |
---|---|
13 isoforms | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.5 | 8.3 | with cumene hydroperoxide as substrate | Homo sapiens |
33 | 94 | with 1-chloro-2,4-dinitrobenzene as substrate | Homo sapiens |
104 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
glutathione + cumene hydroperoxide | - |
Homo sapiens | ? | - |
? | |
RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Homo sapiens | HX + R-S-glutathione | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 25600, form XIII, SDS-PAGE | Homo sapiens |
dimer | 2 * 25200, form I-XII, SDS-PAGE | Homo sapiens |