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Literature summary for 2.5.1.18 extracted from
- Cloning, expression and characterization of human glutathione S-transferase Omega 2 (2005), Int. J. Mol. Med., 16, 19-27.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme GSTO2, cloning from a human fetal brain cDNA library, DNA and amino acid sequence determination and analysis, expression analysis, expression of isozyme GSTO2-EGFP fusion protein in cytoplasm of COS-7 cells and in cytoplasma and nucleus of L-02, QGY-7703 and SMMC-7721 cells, expression of His-tagged isozyme GSTO2 in Escherichia coli strain M15 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | isozyme GSTO2 may play an important role in cellular signaling inducing apoptosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9H4Y5 | isozyme GSTO2; omega class isozymes GSTO1-1 and GSTO2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged isozyme GSTO2 by glutathione affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | isozyme GSTO2 shows wide tissue distribution, expression pattern, overview | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.335 | - |
purified recombinant enzyme, substrate 2-hydroxyethyl disulfide | Homo sapiens |
| 10.45 | - |
purified recombinant enzyme, substrate 1-chloro-2,4-dinitrobenzene in absence of 10 mM EDTA | Homo sapiens |
| 14.56 | - |
purified recombinant enzyme, substrate 1-chloro-2,4-dinitrobenzene in presence of 10 mM EDTA | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1-chloro-2,4-dinitrobenzene | high activity with isozyme GSTO2, not with isozyme GSTO1-1 | Homo sapiens | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 2-hydroxyethyl disulfide | isozyme GSTO2, low activity | Homo sapiens | ? | - |
? | |
| additional information | isozyme GSTO2 may play an important role in cellular signaling inducing apoptosis | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione S-transferase | - |
Homo sapiens |
| GST | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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