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Literature summary for 2.5.1.18 extracted from
- In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity (2006), Xenobiotica, 36, 659-670.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics, single-enzyme Michaelis-Menten model | Mus musculus | |
| additional information | - |
additional information | kinetics, single-enzyme Michaelis-Menten model | Rattus norvegicus | |
| additional information | - |
additional information | kinetics, single-enzyme Michaelis-Menten model | Canis lupus familiaris | |
| additional information | - |
additional information | kinetics, single-enzyme Michaelis-Menten model | Macaca fascicularis | |
| additional information | - |
additional information | kinetics, single-enzyme MichaelisMenten model | Homo sapiens | |
| 0.00324 | - |
cryptophycin 52 | pH 7.4, 37°C | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Canis lupus familiaris | 5829 | - |
| cytosol | - |
Macaca fascicularis | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
beagle dogs | - |
| Homo sapiens | - |
male | - |
| Macaca fascicularis | - |
cynomolgus monkey | - |
| Mus musculus | - |
CD1 mice | - |
| Mus musculus CD1 | - |
CD1 mice | - |
| Rattus norvegicus | - |
Fischer-344 rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | liver enzyme | Mus musculus | - |
| commercial preparation | liver enzyme | Homo sapiens | - |
| commercial preparation | liver enzyme | Rattus norvegicus | - |
| commercial preparation | liver enzyme | Canis lupus familiaris | - |
| commercial preparation | liver enzyme | Macaca fascicularis | - |
| liver | commercial enzyme preparation | Mus musculus | - |
| liver | commercial enzyme preparation | Homo sapiens | - |
| liver | commercial enzyme preparation | Rattus norvegicus | - |
| liver | commercial enzyme preparation | Canis lupus familiaris | - |
| liver | commercial enzyme preparation | Macaca fascicularis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0936 | - |
- |
Homo sapiens |
| 0.119 | - |
- |
Rattus norvegicus |
| 0.146 | - |
- |
Canis lupus familiaris |
| 0.318 | - |
- |
Macaca fascicularis |
| 0.972 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Mus musculus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Canis lupus familiaris | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Macaca fascicularis | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Mus musculus CD1 | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Mus musculus | ? | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Homo sapiens | ? | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Rattus norvegicus | ? | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Canis lupus familiaris | ? | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Macaca fascicularis | ? | - |
? | |
| glutathione + cryptophycin 52 | conjugation with the R-stereoisomer | Mus musculus CD1 | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Mus musculus | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Homo sapiens | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Rattus norvegicus | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Canis lupus familiaris | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Macaca fascicularis | ? | - |
? | |
| glutathione + cryptophycin 53 | conjugation with the S-stereoisomer | Mus musculus CD1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGST | - |
Mus musculus |
| cGST | - |
Homo sapiens |
| cGST | - |
Rattus norvegicus |
| cGST | - |
Canis lupus familiaris |
| cGST | - |
Macaca fascicularis |
| glutathione S-transferase | - |
Mus musculus |
| glutathione S-transferase | - |
Homo sapiens |
| glutathione S-transferase | - |
Rattus norvegicus |
| glutathione S-transferase | - |
Canis lupus familiaris |
| glutathione S-transferase | - |
Macaca fascicularis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
assay at | Canis lupus familiaris |
| 37 | - |
assay at | Macaca fascicularis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Rattus norvegicus |
| 7.4 | - |
assay at | Canis lupus familiaris |
| 7.4 | - |
assay at | Macaca fascicularis |
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Release 2023.1 (January 2023)
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