Literature summary for 2.5.1.2 extracted from

Kelleher, N.L.; Nicewonger, R.B.; Begley, A.P.; McLafferty, F.W.
Identification of modification sites in large biomolecules by stable isotope labeling and tandem high resolution mass spectrometry. The active site nucleophile of thiaminase I (1997), J. Biol. Chem., 272, 32215-32220.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-Amino-6-chloro-2-methylpyrimidine	this suicide substrate is linked to Cys113 of the enzyme	Paenibacillus thiaminolyticus

Organism

Organism	UniProt	Comment	Textmining
Paenibacillus thiaminolyticus	P45741	cloned in Escherichia coli	-

Subunits

Subunits	Comment	Organism
monomer	active site between Pro109 and Phe118, includes nucleophilic site Cys113	Paenibacillus thiaminolyticus

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Release 2023.1 (January 2023)