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Literature summary for 2.5.1.21 extracted from
- Squalene synthetase (1985), Methods Enzymol., 110, 359-373.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| farnesyl diphosphate | no inhibition of presqualene diphosphate synthase reaction; substrate inhibitor of squalene synthase reaction | Saccharomyces cerevisiae |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay methods | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + farnesyl diphosphate | - |
Saccharomyces cerevisiae | diphosphate + presqualene diphosphate | - |
? | |
| presqualene diphosphate + NAD(P)H | in presence of reducing pyridine nucleotide, preferably NADPH, squalene is formed, in absence of reducing cofactor the rate of the condensation reaction is lower and all of the product accumulates as presqualene diphosphate | Saccharomyces cerevisiae | squalene + NAD(P)+ + diphosphate | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | NADH or NADPH required for squalene synthase reaction | Saccharomyces cerevisiae | |
| NADPH | NADPH or NADH required for squalene synthase reaction | Saccharomyces cerevisiae | |
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