Crystallization (Comment) | Organism |
---|---|
mutant with deletion of 47 C-terminal amino acids | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of 30 N-terminal amino acids without effect to activity, additional deletion of 81 to 97 C-terminal amino acids abolishes activity, deletion of only 47 C-terminal amino acids retains activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CP-294838 | a benzoxazepinone IC50 130 nM | Homo sapiens | |
CP-295697 | a bisphosphonate, IC50: 20 nM | Homo sapiens | |
zaragozic acid | IC50 0.7 nM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
farnesyl diphosphate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P37268 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + farnesyl diphosphate | - |
Homo sapiens | diphosphate + presqualene diphosphate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000007 | - |
IC50 0.7 nM | Homo sapiens | zaragozic acid | |
0.00002 | - |
a bisphosphonate, IC50: 20 nM | Homo sapiens | CP-295697 | |
0.00013 | - |
a benzoxazepinone IC50 130 nM | Homo sapiens | CP-294838 |