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Literature summary for 2.5.1.26 extracted from

  • Grimm, M.O.; Kuchenbecker, J.; Rothhaar, T.L.; Groesgen, S.; Hundsdoerfer, B.; Burg, V.K.; Friess, P.; Mueller, U.; Grimm, H.S.; Riemenschneider, M.; Hartmann, T.
    Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimers disease (2011), J. Neurochem., 116, 916-925.
    View publication on PubMed
Search for more literature for 2.5.1.26

Cloned(Commentary)

Cloned (Comment) Organism
AGPS expression anaysis by quantitative RT-PCR analysis Mus musculus
AGPS expression anaysis by quantitative RT-PCR analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of homo- and heterozygous APP knock-out mice, APP-/-, APP+/-, and mice expressing a truncated amyloid precursor protein, APP, the construct lacks the last 15 amino acids, APPDELTA/DELTA, that includes the presumably critical YENPTY motif, where adaptor proteins like Fe65 and X11 are proposed to bind through their phosphotyrosine-binding domains and which are responsible for nuclear targeting of APP intracellular domain Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Mus musculus 5777
-
peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-acyl-glycerone 3-phosphate + a long-chain alcohol Mus musculus
-
 an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
 ?
1-acyl-glycerone 3-phosphate + a long-chain alcohol Homo sapiens
-
 an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acyl-glycerone 3-phosphate + a long-chain alcohol
-
 Mus musculus an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
 ?
1-acyl-glycerone 3-phosphate + a long-chain alcohol
-
 Homo sapiens an alkyl-glycerone 3-phosphate + a long-chain acid anion
-
 ?

Synonyms

Synonyms Comment Organism
AGPS
-
 Mus musculus
AGPS
-
 Homo sapiens
alkyl-dihydroxyacetonephosphate-synthase
-
 Mus musculus
alkyl-dihydroxyacetonephosphate-synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the amyloid precursor protein intracellular domain increases the expression of the alkyl-dihydroxyacetonephosphate-synthase in vivo and in vitro up

General Information

General Information Comment Organism
malfunction AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview Mus musculus
malfunction AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview Homo sapiens
metabolism alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids Mus musculus
metabolism alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids Homo sapiens
physiological function plasmalogens are decreased as a consequence of Alzheimer's disease and regulated by amyloid-beta precursor protein processing under physiological conditions. Under the pathological situation of Alzheimer's disease, increased amyloid-beta levels lead to increased reactive oxidative species production, reduced AGPS protein and plasmalogen level, overview. Alterations in amyloid precursor protein-dependent changes of AGPS expression result in reduced protein and plasmalogen levels Homo sapiens