Literature summary for 2.5.1.26 extracted from

Zhu, Y.; Han, Y.; Ma, Y.; Yang, P.
ADME/toxicity prediction and antitumor activity of novel nitrogenous heterocyclic compounds designed by computer targeting of alkylglycerone phosphate synthase (2018), Oncol. Lett., 16, 1431-1438 .

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Application

Application	Comment	Organism
pharmacology	alkylglycerone phosphate synthase is an oncogene and can be considered as an antitumor drug target. The study designs novel nitrogenous heterocyclic compound improving targetability by computer-aided drug design technology targeting alkylglycerone phosphate synthase. A total of 12 nitrogenous heterocyclic compounds are designed and predicted the absorption, distribution, metabolism and excretion parameters/toxicity. Their activity in terms of proliferation inhibition, cell cycle arrest and apoptosis induction as then measured using an MTS assay and a high-content screening system in U251 cells. The results show that anti-glioma activity is present in several compounds, which is in accordance with the computer prediction. These compounds may be suitable for the development of a glioma therapeutic drug	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00116	-	-

Synonyms

Synonyms	Comment	Organism
AGPS	-	Homo sapiens

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Release 2023.1 (January 2023)