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Literature summary for 2.5.1.29 extracted from

  • Cao, R.; Chen, C.K.; Guo, R.T.; Wang, A.H.; Oldfield, E.
    Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases (2008), Proteins, 73, 431-439.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method, X-ray crystallographic structures of the N-[methyl(4-phenylbutyl)]-3-aminopropyl-1-hydroxy-1,1-bisphosphonate, bound to geranylgeranyl diphosphate synthase Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
N-[methyl(4-phenylbutyl)]-3-aminopropyl-1-hydroxy-1,1-bisphosphonate the bisphosphonate binds only to the GGPP product inhibitory site Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q12051
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