Literature summary for 2.5.1.29 extracted from

Choi, H.J.; Choi, J.Y.; Cho, S.W.; Kang, D.; Han, K.O.; Kim, S.W.; Kim, S.Y.; Chung, Y.S.; Shin, C.S.
Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women (2010), Yonsei Med. J., 51, 231-238.

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Application

Application	Comment	Organism
medicine	women with 2 deletion alleles of GGPS1 -8188A ins/del (rs3840452) have significantly higher femoral neck bone marrow densitiy at baseline compared with those with one or no deletion allele. The response rate of women with 2 deletion alleles of GGPS1 -8188A ins/del (28.6%) is significantly lower than the rate of women with one or no deletion allele. Women with 2 deletion alleles of GGPS1 -8188A ins/del have 7fold higher risk of non-response to bisphosphonate therapy compared with women with other genotypes in GGPS1 -8188. Other polymorphisms in or GGPS1 are not associated with lumbar spine bone marrow density or femoral neck bon marrow density	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	women with 2 deletion alleles of GGPS1 -8188A ins/del (rs3840452) have significantly higher femoral neck bone marrow densitiy at baseline compared with those with one or no deletion allele. The response rate of women with 2 deletion alleles of GGPS1 -8188A ins/del (28.6%) is significantly lower than the rate of women with one or no deletion allele. Women with 2 deletion alleles of GGPS1 -8188A ins/del have 7fold higher risk of non-response to bisphosphonate therapy compared with women with other genotypes in GGPS1 -8188. Other polymorphisms in or GGPS1 are not associated with lumbar spine bone marrow density or femoral neck bon marrow density	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Korean women	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
GGSP1	-	Homo sapiens

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Release 2023.1 (January 2023)