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Literature summary for 2.5.1.3 extracted from

  • Khare, G.; Kar, R.; Tyagi, A.K.
    Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs (2011), PLoS ONE, 6, e22441.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
3-benzylsulfanyl-phenanthro[9,10-e][1,2,4]triazine IC50 of 0.1 mg/ml Mycobacterium tuberculosis
4-[[(2-hydroxy-5-nitrophenyl)methylidene]amino]-5-methyl-2-(propan-2-yl)phenol IC50 of 0.034 mg/ml Mycobacterium tuberculosis
7-[[4-chloro-6-(diethylamino)-s-triazin-2-yl]amino]-3-phenyl-coumarin IC50 of more than 0.1 mg/ml Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 x * 29000, SDS-PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
strep - tactin column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
-
 Mycobacterium tuberculosis thiamine phosphate + diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 29000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
thiamin phosphate synthase
-
 Mycobacterium tuberculosis
TPS
-
 Mycobacterium tuberculosis