Literature summary for 2.5.1.31 extracted from

Chen, A.P.; Chen, Y.H.; Liu, H.P.; Li, Y.C.; Chen, C.T.; Liang, P.H.
Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase (2002), J. Am. Chem. Soc., 124, 15217-15224.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-farnesyl thiodiphosphate	an extremely poor substrate for UPPs	Escherichia coli
7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate	competitive inhibitor, substrate analogue prepared and utilized to study ligand interactions	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00069	-	7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate	alternative substrate, pH 7.5, 25°C	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate	-	Escherichia coli	8 diphosphate + ditrans,octacis-undecaprenyl diphosphate	-	?
7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate + isopentenyl diphosphate	fluorescent analogue of (2E,6E)-farnesyl diphosphate, alternative substrate and inhibitor	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
undecaprenyl pyrophosphate synthase	-	Escherichia coli
UPPs	-	Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.02	-	7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate	alternative substrate, pH 7.5, 25°C	Escherichia coli

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00057	-	7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate	(2E,6E)-farnesyl diphosphate as a substrate, pH 7.5, 25°C	Escherichia coli

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Release 2023.1 (January 2023)