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Literature summary for 2.5.1.46 extracted from

  • Wolff, E.C.; Folk, J.E.; Park, M.H.
    Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase (1997), J. Biol. Chem., 272, 15865-15871.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-amino-7-guanidinoheptane competitive, inhibits binding of spermidine to the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine Homo sapiens first step in the biosynthesis of hypusine [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?
[eIF5A-precursor]-lysine + spermidine first step in the biosynthesis of hypusine Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens