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Literature summary for 2.5.1.46 extracted from

  • Ziegler, P.; Chahoud, T.; Wilhelm, T.; Paellman, N.; Braig, M.; Wiehle, V.; Ziegler, S.; Schroeder, M.; Meier, C.; Kolodzik, A.; Rarey, M.; Panse, J.; Hauber, J.; Balabanov, S.; Bruemmendorf, T.H.
    Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias (2012), Invest. New Drugs, 30, 2274-2283.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
deoxyspergualin
-
Homo sapiens
deoxyspergualin
-
Mus musculus
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]decanediamide-tetrahydrochloride i.e. CNI-1493 Homo sapiens
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]decanediamide-tetrahydrochloride i.e. CNI-1493 Mus musculus
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]dodecanediamide-tetrahydrochloride i.e. DHSI-15 Homo sapiens
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]dodecanediamide-tetrahydrochloride i.e. DHSI-15 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
32D cell
-
Mus musculus
-
BA/F3 cell
-
Mus musculus
-
cell culture DHS is ubiquitously expressed in primary mouse cells and murine cell lines Mus musculus
-
culture condition:CD34+ cell
-
Homo sapiens
-
MEF cell
-
Mus musculus
-
additional information DHS is ubiquitously expressed in CD34+ cellss from patients with chronic myeloid leukemia and acute myeloid leukemia Homo sapiens
-
NIH-3T3 cell
-
Mus musculus
-
NIH-3T3 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
DHS
-
Mus musculus
DHS
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of proliferation of BA/F3 p210 cells including the imatinib resistant mutants M351T, E255K, and T315I by deoxyhypusine synthase inhibitors Mus musculus
additional information inhibition of eIF5A by siRNA or DHS-inhibitors in combination with Imatinib exerts synergistic cytotoxic effects on BCR-ABL positive cell lines Homo sapiens