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Literature summary for 2.5.1.46 extracted from

  • Preukschas, M.; Hagel, C.; Schulte, A.; Weber, K.; Lamszus, K.; Sievert, H.; Paellmann, N.; Bokemeyer, C.; Hauber, J.; Braig, M.; Balabanov, S.
    Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies (2012), PLoS ONE, 7, e43468.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.46

Protein Variants

Protein Variants Comment Organism
additional information DHS knock-down by stable lentiviral expression of shRNAs in G55T2 and U87-MG cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GC7 a specific DHS-inhibitor, inhibits DHS by competitive replacement of its native spermidine substrate. Inhibition of DHS by GC7 induces antiproliferative effects in vitro. The compound shows a strong antiproliferative effect in glioblastoma cell lines in vitro, while normal human astrocytes are not affected, and it causes p53 dependent premature senescence, a permanent cell cycle arrestin U-MG 87 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
NCE-G55T2 cell
-
 Homo sapiens
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U-87MG cell
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DHS
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of DHS by GC7 induces antiproliferative effects in vitro. GC7 treatment induces premature senescence in U87-MG cells, co-treatment of glioblastoma cells with TMZ/BCNU and GC7 has an additive antiproliferative effect Homo sapiens