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Literature summary for 2.5.1.48 extracted from

  • Kaplan, M.; Guggenheim, S.
    Cystathionine gamma-synthase (Salmonella) (1971), Methods Enzymol., 17B, 425-433.
No PubMed abstract available
Search for more literature for 2.5.1.48

Inhibitors

Inhibitors Comment Organism Structure
beta-mercaptopropionate competitive inhibitor of gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium
chloromercuriphenylsulfonate inhibition of gamma-elimination Salmonella enterica subsp. enterica serovar Typhimurium
cystathionine competitive, gamma-elimination Salmonella enterica subsp. enterica serovar Typhimurium
D-cysteine inhibition of gamma-elimination Salmonella enterica subsp. enterica serovar Typhimurium
L-homocysteine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N-ethylmaleimide inhibition of gamma-elimination Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
 sedimentation equilibrium centrifugation Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
80% homogenous Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18.2
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Storage Stability

Storage Stability Organism
-15°C, protein concentration 10 mg/ml, 6-12 months stable Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-acetyl-L-homoserine + L-cysteine gamma-replacement Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + acetate
-
 ?
O-succinyl-L-homoserine + CH3SH
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-methionine + succinate
-
 ?
O-succinyl-L-homoserine + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium succinate + 2-oxobutyrate + NH3
-
 ?
O-succinyl-L-homoserine + H2S
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-homocysteine + succinate
-
 ?
O-succinyl-L-homoserine + L-cysteine
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + succinate
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate 4 mol tightly bound per mol of enzyme Salmonella enterica subsp. enterica serovar Typhimurium