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Literature summary for 2.5.1.54 extracted from

  • Görisch, H.; Lingens, F.
    3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens Tü 24 (1971), Biochim. Biophys. Acta, 242, 630-636.
    View publication on PubMed
Search for more literature for 2.5.1.54

Inhibitors

Inhibitors Comment Organism Structure
2-Methyl-DL-Trp 0.02 mM, 30% inhibition Kitasatospora aureofaciens
4-Methyl-DL-Trp 0.02 mM, 30% inhibition Kitasatospora aureofaciens
5-Fluoro-DL-Trp 0.02 mM, 56% inhibition Kitasatospora aureofaciens
5-hydroxy-DL-Trp 0.02 mM, 10% inhibition Kitasatospora aureofaciens
6-Methyl-DL-Trp 0.02 mM, 6% inhibition Kitasatospora aureofaciens
7-Aza-DL-Trp 0.02 mM, 9% inhibition Kitasatospora aureofaciens
7-Methyl-DL-Trp 0.02 mM, 14% inhibition Kitasatospora aureofaciens
DL-Dibromotryptophan 0.02 mM, 52% inhibition Kitasatospora aureofaciens
DL-erythro-beta-Methyltryptophan 0.02 mM, 40% inhibition Kitasatospora aureofaciens
DL-Homotryptophan 0.02 mM, 46% inhibition Kitasatospora aureofaciens
N-alpha-methyl-DL-Trp 0.02 mM, 60% inhibition Kitasatospora aureofaciens
Trp 0.02 mM, 65% inhibition; non-competitive against phosphoenolpyruvate and competitive for D-erythrose 4-phosphate; strongly dependent on pH; Trp-sensitive isozyme Kitasatospora aureofaciens

Organism

Organism UniProt Comment Textmining
Kitasatospora aureofaciens
-
 strain Tü 24
-
Kitasatospora aureofaciens Tu24
-
 strain Tü 24
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Kitasatospora aureofaciens 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Kitasatospora aureofaciens Tu24 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?