Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-erythrose 4-phosphate | substrate-inhibition | Neurospora crassa | |
phosphate | competitive to D-erythrose 4-phosphate, noncompetitive to phosphoenolpyruvate | Neurospora crassa | |
Trp | allosteric, best at pH 6.0, no inhibition at pH 7.3; Trp-sensitive isozyme | Neurospora crassa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neurospora crassa | - |
- |
- |
Neurospora crassa | - |
tryptophan-sensitive isozyme | - |
Neurospora crassa 74A | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Neurospora crassa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate | ordered ping-pong bi-bi mechanism | Neurospora crassa | |
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate | first substrate is phosphoenolpyruvate | Neurospora crassa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | - |
Neurospora crassa | 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate | - |
? | |
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | - |
Neurospora crassa 74A | 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
phosphoenolpyruvate, D-erythrose 4-phosphate and inorganic phosphate protect the purified enzyme against heat denaturation | Neurospora crassa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
tryptophan-sensitive isozyme | Neurospora crassa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
22 | - |
phosphate | slope, tryptophan-sensitive isozyme, versus phosphoenolpyruvate, pH 7.4, 37°C | Neurospora crassa | |
25 | - |
phosphate | slope, tryptophan-sensitive isozyme, versus D-erythrose 4-phosphate, pH 7.4, 37°C | Neurospora crassa | |
54 | - |
phosphate | intercept, tryptophan-sensitive isozyme, versus phosphoenolpyruvate, pH 7.4, 37°C | Neurospora crassa |