Literature summary for 2.5.1.58 extracted from

Buckner, F.S.; Yokoyama, K.; Nguyen, L.; Grewal, A.; Erdjument-Bromage, H.; Tempst, P.; Strickland, C.L.; Xiao, L.; Van Voorhis, W.C.; Gelb, M.H.
Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei (2000), J. Biol. Chem., 275, 21870-21876.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in bloodstream and insect stage parasites, and expression in Escherichia coli	Trypanosoma brucei brucei

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei brucei	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Trypanosoma brucei brucei

Source Tissue

Source Tissue	Comment	Organism	Textmining
bloodstream form	-	Trypanosoma brucei brucei	-
procyclic form	-	Trypanosoma brucei brucei	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme	Trypanosoma brucei brucei	diphosphate + S-farnesyl protein	-	?

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Release 2023.1 (January 2023)