Application | Comment | Organism |
---|---|---|
medicine | - |
Trypanosoma cruzi |
medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Leishmania amazonensis |
medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Trypanosoma cruzi |
medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Leishmania major |
Cloned (Comment) | Organism |
---|---|
coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Trypanosoma brucei brucei |
coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Trypanosoma cruzi |
coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Leishmania major |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Trypanosoma brucei brucei | |
Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Trypanosoma cruzi | |
Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | - |
- |
- |
Leishmania amazonensis LV78 | - |
- |
- |
Leishmania major | Q8WR00 | beta-subunit | - |
Leishmania major | Q8WR01 | alpha-subunit | - |
Trypanosoma brucei brucei | - |
- |
- |
Trypanosoma cruzi | Q8WR02 | Tulahuen, beta-subunit | - |
Trypanosoma cruzi | Q8WR03 | Tulahuen, allelic form II of the alpha-subunit | - |
Trypanosoma cruzi | Q8WR04 | Tulahuen, allelic form I of the alpha-subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Leishmania major | - |
epimastigote | - |
Trypanosoma cruzi | - |
procyclic form | - |
Trypanosoma brucei brucei | - |
promastigote | - |
Leishmania major | - |
trypomastigote | - |
Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | - |
Leishmania amazonensis | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Trypanosoma brucei brucei | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Trypanosoma cruzi | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Leishmania major | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | - |
Leishmania amazonensis LV78 | diphosphate + S-farnesyl protein | - |
? |