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Literature summary for 2.5.1.58 extracted from

  • Qian, D.; Zhou, D.; Ju, R.; Cramer, C.L.; Yang, Z.
    Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control (1996), Plant Cell, 8, 2381-2394.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.58

Cloned(Commentary)

Cloned (Comment) Organism
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 Pisum sativum

Inhibitors

Inhibitors Comment Organism Structure
manumycin inhibition at concentration as low as 0.0025 mM, inhibitor most likely to affect only the processes that involve protein isoprenylation Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
farnesyl diphosphate + protein-cysteine Pisum sativum potential role for plant enzyme in cell cycle regulation S-farnesyl protein + diphosphate
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 ?
farnesyl diphosphate + protein-cysteine Nicotiana tabacum potential role for plant enzyme in cell cycle regulation S-farnesyl protein + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
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 BY-2 cells
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Pisum sativum
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + protein-cysteine
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 Nicotiana tabacum diphosphate + S-farnesyl protein
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 ?
farnesyl diphosphate + protein-cysteine posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln Pisum sativum diphosphate + S-farnesyl protein
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 ?
farnesyl diphosphate + protein-cysteine prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F Pisum sativum diphosphate + S-farnesyl protein
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 ?
farnesyl diphosphate + protein-cysteine potential role for plant enzyme in cell cycle regulation Pisum sativum S-farnesyl protein + diphosphate
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 ?
farnesyl diphosphate + protein-cysteine potential role for plant enzyme in cell cycle regulation Nicotiana tabacum S-farnesyl protein + diphosphate
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 ?

Subunits

Subunits Comment Organism
More alpha-subunit of enzyme plays a role in binding isoprenyl substrates Pisum sativum