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Literature summary for 2.5.1.58 extracted from

  • Reid, T.S.; Terry, K.L.; Casey, P.J.; Beese, L.S.
    Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity (2004), J. Mol. Biol., 343, 417-433.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
FTase in ternary complexes with an FPP analog and peptides derived from the cognate substrates H-Ras (GCVLS) and Rap2a (DDPTA-SACNIQ), the cross-reactive substrate TC21 (KKSKTKCVIF), and the non-substrate Rap2b (TKCVIL). Structures of GGTase-I in ternary complexes with a GGPP analog (3'azaGGPP) and peptides derived from the cognate substrates Cdc42 splice isoform 2 (RRCVLL Ca1a2X motif) and the heterotrimeric G protein g2 subunit (FREKKFFCAIL), and the cross-reactive substrates RhoB (GCINCCKVL), K-Ras4B (KKKSKTKCVIM) and TC21 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
FTase
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Homo sapiens