Literature summary for 2.5.1.58 extracted from

Kim, S.J.; Kwon, B.; Kim, S.; Baek, N.; Yang, J.H.; Lee, J.J.; Lee, S.I.; Kwon, Y.; Park, H.W.; Lee, J.H.; Park, J.; Kim, D.K.
Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon (2007), Nat. Prod. Sci., 13, 328-331.

No PubMed abstract available

Search for more literature for 2.5.1.58

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in baculovirus	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acetylshikonin	inhibits FTPase activity in a dose-dependent manner	Homo sapiens
acetylshikonin	inhibits FTPase activity in a dose-dependent manner	Rattus norvegicus
deoxyshikonin	inhibits FTPase activity in a dose-dependent manner	Homo sapiens
deoxyshikonin	inhibits FTPase activity in a dose-dependent manner	Rattus norvegicus
shikonine	inhibits FTPase activity in a dose-dependent manner	Homo sapiens
shikonine	inhibits FTPase activity in a dose-dependent manner	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens
ammonium sulfate fractionation and Q Sepharose column chromatography	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	-	Homo sapiens	diphosphate + S-farnesyl protein	-	?
farnesyl diphosphate + protein-cysteine	-	Rattus norvegicus	diphosphate + S-farnesyl protein	-	?

Synonyms

Synonyms	Comment	Organism
farnesyl protein transferase	-	Homo sapiens
farnesyl protein transferase	-	Rattus norvegicus
fptase	-	Homo sapiens
fptase	-	Rattus norvegicus

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Release 2023.1 (January 2023)